Emerging IR 4.0 systems have the capacity both negatively and positively to disrupt. While currently much of the design in this regard has for practical reasons focused on technical systems, there is an urgent need to ensure that these systems due to their physical fabrication, pervasive deployment, and autonomous capabilities, are integrated into our human world in a manner that enhances the human condition and ensure planetary sustainment. Supporting this urgent need, this paper suggests that human-centred design (HCD) can make a substantial contribution, albeit with a recasting of its traditional design role.